We are interested in
understanding how cells
establish monopolar and bipolar growth patterns and how these patterns
contribute to cell shape.
collaboration with the lab of Fulvia Verde (University of Miami) we studied
the kinetics of polarity protein Cdc42 that exhibits anti-correlated
oscillations at cell tips. Click
here to read about our model of Cdc42 oscillations and how they
contribute to the initiation of bipolar growth.
In collaboration with the group of Sophie
Martin (University of Lausanne) we study how cells polarize toward their
mating partners during fission yeast mating. We have modeled the exploratory
search for a partner as an optimization strategy. We also modeled the
molecular mechanisms driving this exploration based on the local activation
Our group has
proposed models of how formin-mediated actin cables assemble at cell tips in
fission and budding yeast.
A graphical Java simulation of
a model of actin cable turnover allowing the user to change parameters values is available
H. Tang, T. C. Bidone, D. Vavylonis,
"Computational model of polarized actin cables and contractile
actin ring formation in
H. Tang, D. Laporte and D. Vavylonis, "Actin cable distribution and
dynamics arising from cross-linking, motor-pulling and filament
T. Drake and D.
Vavylonis, "Model of fission yeast cell shape driven by membrane-bound
growth factors and the cytoskeleton," PLOS
M. Das, T. Drake, D.
Buchwald, D. Vavylonis and F. Verde, "Oscillatory dynamics of Cdc42 GTPase
in the control of polarized growth," SCIENCE
T. Drake, E. Yusuf and D. Vavylonis, "A
Systems-Biology Approach to Yeast Actin Cables", in "Advances in
Systems Biology", Springer series Advances in Experimental Medicine and
Biology, 736:325-35 (2012).
T. Drake and D.
Vavylonis, "Cytoskeletal Dynamics in Fission Yeast: A Review of Models
for Polarization and Division," HFSP J., 4 122-130 (2010).
H. Wang and D.
Vavylonis, "Model of For3p-mediated actin cable assembly in fission yeast,"
3 e4078 (2008).
B. Khalili, L. Merlini, V. Vincenzetti, S. G. Martin, and D. Vavylonis,
"Exploration and Stabilization of Ras1 Mating Zone: a Mechanism with
Positive and Negative Feedbacks" (2017, submitted).
L. Merlini, B. Khalili, F. O.
Bendezú, D. Hurwitz,
V. Vincenzetti, D. Vavylonis, S. M. Martin, "Local pheromone release
from dynamic polarity sites underlies cell-cell pairing during yeast
BIOLOGY 26:1117-1125 (2016).